Abstract

Occurrence of hepatic diseases being one of the major sources of death associated with HIV people equivalent topotent antiretroviral drugs. This study evaluates the effects of Lamivudine on selected liver enzymes (aspartate amino transferase (AST), alanine amino transferase (ALT) and alkaline phosphatase (ALP)) in Wistar rats. Fifty two (52) Wistar rats were selected randomly into groups of four (4); group 1 received distilled water, group 2 to 4 were administered with 25 75 and 100% in mg/kg body weight of Lamivudine. Thevarious experimental groups were pre-disposed to the same conditions. Drugs was orally administered daily although 33 days. Animals were sacrificed in batches includes; eleven (11) days of exposure, twenty two (22) days of exposure and lastly, thirty three (33) days of exposure. Whole Blood samples were collected into sample bottles for hepatic function test. The result showed that, the effect is concentration and time dependent. The significant difference (P<0.05) showed reduction in ALT, AST and ALP at lower concentration (25%) in days 11, 22 and 33 (21.75±14.52, 102.75±68.59 and 112.75±75.17), (31.25±4.27, 121.25±3.40 and 167.50±5.97) and (23.00±15.43, 92.75±61.89 and 125.00±83.53) when compared with the control group (29.50±3.54, 109.00±2.83 and 138.00±12.73). While at medium and highest concentrations showed significant increased in days 11, 22 and 33 when compared with the control group. In conclusion, treatment with increased and prolonged doses of Lamivudine may result to hepaticinjuryas observed from the drastic increase liver function test parameters.